Nuclease

A nuclease is an enzyme capable of cleaving the phosphodiester bonds between nucleotides of nucleic acids. Nucleases variously effect single and double stranded breaks in their target molecules. In living organisms, they are essential machinery for many aspects of DNA repair. Defects in certain nucleases can cause genetic instability or immunodeficiency. Nucleases are also extensively used in molecular cloning.

Daniel Voytas

Daniel Voytas, Ph.D., is Professor of Genetics, Cell Biology and Development at the University of Minnesota and Director of the Center for Precision Plant Genomics. He is also the Chief Scientific Officer of Calyxt, an agricultural biotechnology company

IPO5

Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the importin beta family. Structurally, the protein adopts the shape of a right hand solenoid and is composed of 24 HEAT repeats

Meganuclease

Meganucleases are endodeoxyribonucleases characterized by a large recognition site ; as a result this site generally occurs only once in any given genome. For example, the 18-base pair sequence recognized by the I-SceI meganuclease would on average

Denizli Province

Denizli Province is a province of Turkey in Western Anatolia, on high ground above the Aegean coast. Neighbouring provinces are Uşak to the north, Burdur, Isparta, Afyon to the east, Aydın, Manisa to the west and Muğla to the south. It is located

Maturation promoting factor

Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs. It stimulates the mitotic and meiotic phases of the cell cycle. MPF promotes

Transcription activator-like effector

TAL effectors are proteins secreted by some β- and γ-proteobacteria. Most of these are Xanthomonads. Plant pathogenic Xanthomonas bacteria are especially known for TALEs, produced via their type III secretion system. These proteins can bind promoter

André Choulika

André Choulika is a biotechnologist, the inventor of nuclease-based genome editing and a pioneer in the analysis and use of meganucleases to modify complex genomes

Council for Scientific Policy

The Council for Scientific Policy, 1965-1972, was a council set up in the United Kingdom by the secretary of state. The council advised the secretary of state on all aspects of his responsibilities with reference to science policy

Fatih University

Fatih University was a leading private (foundation) university located in the metropolitan Büyükçekmece district of Istanbul, Turkey. Founded in 1996, the university was closed by the Turkish government in July 2016 and is now a part of Istanbul

Homotopic connectivity

In biology, homotopic connectivity is the connectivity between mirror areas of the human brain hemispheres