2021 Biella Challenger VI – Singles
Juan Pablo Varillas was the defending champion but chose not to defend his title.
- 2021 Aspria Tennis Cup – Doubles
- Tomislav Brkić and Ante Pavić were the defending champions but chose not to defend their title
- 2021 Antalya Challenger IV – Doubles
- Riccardo Bonadio and Giovanni Fonio were the defending champions but withdrew from the tournament before their quarterfinal match
- 2021 Internationaux de Tennis de Vendée – Doubles
- Jonny O'Mara and Ken Skupski were the defending champions but only O'Mara chose to defend his title, partnering Treat Huey. O'Mara lost in the first round to Antoine Hoang and Kyrian Jacquet
- 2021 Brest Challenger – Doubles
- Denys Molchanov and Andrei Vasilevski were the defending champions but only Molchanov chose to defend his title, partnering Aleksandr Nedovyesov. Molchanov lost in the semifinals to Sadio Doumbia and Fabien Reboul
- 2022 Sanremo Challenger – Doubles
- This was the first edition of the tournament since it was discontinued in 2011
- 2021 Wolffkran Open – Doubles
- Andre Begemann and David Pel were the defending champions but only Begemann chose to defend his title, partnering Igor Zelenay
- 2021 Florianópolis Challenger – Doubles
- This was the first edition of the tournament
- 2022 San Luis Open Challenger – Doubles
- Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions but only Reyes-Varela chose to defend his title, partnering Nicolás Barrientos. Reyes-Varela successfully defended his title, defeating Luis David Martínez and Felipe Meligeni
- 2021 ATP Salzburg Open – Doubles
- Martin Fischer and Philipp Oswald were the defending champions but chose not to defend their title
- 2022 L'Open 35 de Saint-Malo – Singles
- Viktorija Golubic was the defending champion, but chose not to participate