2021 Amstelveen Women's Open – Doubles

This was the first edition of the tournament.

2021 Christus Health Pro Challenge – Singles: Ann Li was the defending champion but chose to compete at the 2021 Courmayeur Ladies Open instead
2019 WSG Open – Singles: Olga Ianchuk was the defending champion, but chose not to participate
2019 Berkeley Tennis Club Challenge – Singles: Sofia Kenin was the defending champion, but chose not to participate
2021 Koser Jewelers Tennis Challenge – Doubles: Vania King and Claire Liu were the defending champions, having won the previous edition in 2019 however King retired from professional tennis in April, whilst Liu chose not to participate
2019 Koser Jewelers Tennis Challenge – Singles: Madison Brengle was the defending champion, and successfully defended her title, defeating Zhu Lin in the final, 6–4, 7–5
2019 Ladies Open Hechingen – Singles: Ekaterine Gorgodze was the defending champion, but chose to participate in Warsaw instead
2021 LTP Charleston Pro Tennis II – Singles: Caroline Dolehide was the defending champion, having won the previous edition in 2019, however she chose to participate in qualifying for Wimbledon instead
2021 Portugal Ladies Open – Singles: Isabella Shinikova was the defending champion but chose to compete at the 2021 BGL Luxembourg Open instead
2019 Al Habtoor Tennis Challenge – Doubles: Alena Fomina and Valentina Ivakhnenko were the defending champions, but lost in the semifinals to Georgina García Pérez and Sara Sorribes Tormo
2022 Koper Open – Doubles: This was the first edition of the tournament